Neuropeptide Y reduces ovarian blood flow in the rabbit

Journal Article · Tue May 01 04:00:00 EDT 1990 · Peptides (Fayetteville, New York); (USA)

DOI:https://doi.org/10.1016/0196-9781(90)90041-3· OSTI ID:6619971

Jorgensen, J C; Sejrsen, P ^[1]

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1. Univ. of Copenhagen (Denmark)

Neuropeptide Y-containing nerve fibers have previously been demonstrated to innervate the mammalian ovary. These nerve fibers innervate primarily the vasculature. In this study we have developed a method for in vivo measurement of the ovary blood flow rate by means of the {sup 133}Xe method. Using this technique we measured the ovary blood flow rate and investigated the dose-response relationship between close intraarterial-injected NPY and the ovary blood flow rate. A monoexponential washout curve for {sup 133}Xe was found for the whole washout process, ensuring that the blood flow rate at any time could be calculated from the curve. We found a mean blood flow rate in the nonpregnant rabbit ovary at 43.6 +/- 4.4 ml.(100 g)-1.min-1 (mean +/- SEM). Injection of NPY (20, 200, 2000 pM) in the aorta close to a. ovarica resulted in a dose-dependent decrease in the ovarian blood flow rate with a maximum reduction to 40.7 +/- 6.3% (mean +/- SEM) of the control blood flow rate. These findings make it likely that receptors able to interact with NPY are present in the vasculature of the rabbit ovary.

• OSTI ID: 6619971
• Journal Information: Peptides (Fayetteville, New York); (USA), Journal Name: Peptides (Fayetteville, New York); (USA) Vol. 11:3; ISSN 0196-9781; ISSN PPTDD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
FEMALE GENITALS
GONADS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NERVES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OVARIES
PEPTIDES
PROTEINS
RABBITS
RADIOISOTOPES
TRACER TECHNIQUES
VERTEBRATES
XENON 133
XENON ISOTOPES