Monoexponential analysis of /sup 133/Xe clearance curves for regional cerebral blood flow measurements

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1984.34· OSTI ID:6885333

Ryding, E

The theoretical properties of a monoexponential flow index, analogous to the one used earlier by other investigators for regional CBF (rCBF) measured after intraarterial injection, were investigated after the administration of /sup 133/Xe intraarterially, intravenously, and by inhalation under high and low flow conditions. The sensitivity of the flow index to changes in fast flow components or changes in the weight ratio between the fast and the slow flow compartments was found to be dependent on whichever part of the /sup 133/Xe clearance curve was used for the flow calculation and on the shape of the input function for /sup 133/Xe. Since biexponential analysis of the clearance curves includes a monoexponential approximation for each of the two components of the clearance curve corresponding to the high and the low flow ''families'' in the brain, the limitations of the monoexponential flow index observed are in principle also valid for the results of biexponential analysis of the clearance curves.

• Research Organization: Department of Clinical Neurophysiology, University Hospital, Lund, Sweden
• OSTI ID: 6885333
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 4:2; ISSN JCBMD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD-PLASMA CLEARANCE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
CLEARANCE
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TRACER TECHNIQUES
XENON 133
XENON ISOTOPES