Regional cerebral blood flow and focal cortical perfusion: a comparative study of /sup 133/Xe, /sup 85/Kr, and umbelliferone as diffusible indicators

Journal Article · Wed Apr 01 04:00:00 EST 1987 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1987.46· OSTI ID:6522436

Anderson, R E; Sundt, Jr, T M; Yaksh, T L

We report that regional CBF determined by the initial slope technique using /sup 133/Xe and /sup 85/Kr in cats and rabbits can be significantly influenced by the size of the field of measurement. The clearance curves of umbelliferone, a lipid-soluble intracellular pH fluorescent indicator, from a visually avascular 80-micron field were used to cross-correlate rCBF with focal cortical perfusion. Our findings indicate that in the cat, as the gamma or beta detector's field of volume was reduced, regional CBF (rCBF) measured by intraarterially injected /sup 133/Xe or /sup 85/Kr decreased in value by 33% and 28%, respectively, and the slope of the rCBF-PaCO/sub 2/ response curve became less steep by 56% and 45%, respectively. Umbelliferone, measuring a much smaller volume of tissue, showed a lower normocapnic flow and a more oblique PaCO/sub 2/ response curve. In the rabbits studied, the normocarbic rCBFs and the rCBF-PaCO/sub 2/ response curves measured with the three techniques corresponded to those measured in the cat. These results suggest that large field/volume measurements assess a measure of flow that is a weighted average of several distinct flow compartments and that these compartments differ in their response to changes in PaCO/sub 2/.

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 6522436
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 2; ISSN JCBMD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 85
KRYPTON ISOTOPES
MAMMALS
MEASURING METHODS
NERVOUS SYSTEM
NUCLEI
ORGANS
RABBITS
RADIOISOTOPES
SCINTILLATION COUNTING
VERTEBRATES
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES