The effect of pancreatic polypeptide and peptide YY on pancreatic blood flow and pancreatic exocrine secretion in the anesthetized dog

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Pancreas; (USA)

DOI:https://doi.org/10.1097/00006676-199101000-00002· OSTI ID:6060035

DeMar, A R; Lake, R; Fink, A S ^[1]

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1. Cincinnati VAMC, OH (USA)

Pancreatic polypeptide (PP) and peptide YY (PYY) are inhibitors of pancreatic exocrine secretion in vivo but not in vitro, which suggests intermediate mechanisms of action. To examine the role of pancreatic blood flow in these inhibitory effects, xenon-133 gas clearance was used to measure pancreatic blood flow while simultaneously measuring pancreatic exocrine secretion. PP or PYY (400 pmol/kg/h) was administered during the intermediate hour of a 3-h secretin (125 ng/kg/h)/cholecystokinin octapeptide (CCK-8) (50 ng/kg/h) infusion. Exocrine secretion and pancreatic blood flow during the PP or PYY hours were compared with that observed in the first and third hours of the secretin/CCK-8 infusion. PP and PYY significantly inhibited secretin/CCK-8-induced pancreatic exocrine secretion. In addition, PYY (but not PP) significantly reduced pancreatic blood flow during secretin/CCK-8 stimulation. Nevertheless, there was no correlation between pancreatic blood flow and bicarbonate or protein outputs. It is concluded that changes in pancreatic blood flow do not mediate the inhibitory effects of PP or PYY on the exocrine pancreas.

• OSTI ID: 6060035
• Journal Information: Pancreas; (USA), Journal Name: Pancreas; (USA) Vol. 6:1; ISSN PANCE; ISSN 0885-3177
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BLOOD FLOW
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
INHIBITION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PEPTIDES
PROTEINS
RADIOISOTOPES
VERTEBRATES
XENON 133
XENON ISOTOPES