Drug development against nuclear and chemical threats: development of new prophylactic radioprotective agents. Final annual report, 15 June 1985-14 August 1987
Technical Report
·
OSTI ID:5468213
This study were is concerned with the preparation of analogs of (WR2721) with modifications in the terminal amine function as potentially new prophylactic radioprotective agents. General methods were developed for the synthesis of WR2721 analogs that possess amide (-C(=0)NHR), thioamide (-C(=S)NHR) and amidine (-C(=NX)NH/sub 2/) terminal residues. In addition, methods were developed for the synthesis of 2-thioxo-3-thiazolidines and 5,6-dihydro-1,2,4,3(4H)-dithiazinethiones as new sulfur masked analogs of (WR1065). During the contract period, a total of twenty-eight (28) target compounds were prepared and submitted for radioprotector screening. No test data is available at this time.
- Research Organization:
- Research Triangle Inst., Research Triangle Park, NC (USA)
- OSTI ID:
- 5468213
- Report Number(s):
- AD-A-187603/6/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560100* -- Biomedical Sciences
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDINES
AMINES
CHEMICAL PREPARATION
CHEMICAL WARFARE AGENTS
DATA
DOCUMENT TYPES
DRUGS
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
MEDICINE
NONMETALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PREVENTIVE MEDICINE
PROGRESS REPORT
RADIOPROTECTIVE SUBSTANCES
RESIDUES
SULFUR
SULFUR COMPOUNDS
SYNTHESIS
WEAPONS
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDINES
AMINES
CHEMICAL PREPARATION
CHEMICAL WARFARE AGENTS
DATA
DOCUMENT TYPES
DRUGS
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
MEDICINE
NONMETALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PREVENTIVE MEDICINE
PROGRESS REPORT
RADIOPROTECTIVE SUBSTANCES
RESIDUES
SULFUR
SULFUR COMPOUNDS
SYNTHESIS
WEAPONS