Biodistribution of the radioprotective drug /sup 35/S-labeled 3-amino-2-hydroxypropyl phosphorothioate (WR77913)

Journal Article · Mon Apr 01 04:00:00 EST 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576436· OSTI ID:5722060

Rasey, J S; Grunbaum, Z; Krohn, K A; Menard, T W; Spence, A M

3-Amino-2-hydroxypropyl phosphorothioate (WR77913), a less toxic phosphorothioate radioprotector than WR2721, has been labeled with /sup 35/S. The biodistribution of a radioprotective dose of 800 mg/kg was determined in C3H mice bearing RIF-1 tumors as a function of time after intraperitoneal injection and was expressed as percentage injected dose/gram (% ID/g). Levels of /sup 35/S in the blood peaked 10 min after injection, and radioactivity in most tissues was highest at 15 min. Label in most tissues declined markedly between 15 and 60 min, but in gut, salivary glands, tumor, and brain, the levels of radioactivity remained quite stable over 1 hr. Two principal differences between the distribution of label from WR77913 and WR2721 were defined. Although blood levels of /sup 35/S-WR2721 also peaked 10 min after injection, the 10-min blood levels achieved for WR77913 were more than fourfold greater than those attained by WR2721. Maximum levels of WR2721 occurred in most tissues 30 to 60 min after administration of the drug, compared to 15 min for WR77913. The basis for these differences remains to be determined, but these results suggest that the optimum interval between administration of WR77913 and irradiation may be shorter than for WR2721.

• Research Organization: Univ. of Washington Medical School, Seattle
• OSTI ID: 5722060
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
GLANDS
HEART
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
LUNGS
MAMMALS
MICE
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SALIVARY GLANDS
SULFUR 35
SULFUR ISOTOPES
THIOLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES