Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5760059
5-thio-D-glucose (5-TDG) exerts profound effects on rapidly metabolizing tissues. We have used liquid scintillation counting to study the tissue distribution and pharmacokinetics of S-35-labeled 5-TDG in hamster models of pancreatic tumors. In the normal hamster, initial uptake of S-35 activity into kidney, liver, and blood was high, but rapidly decreased with time. The pancreatic uptake (% dose/g) never exceeded 0.75%. This level occurred only at the earliest times after administration. Uptake in all three tumor models exceeded that in pancreatic tissue within 15 min of injection. The highest tumor-to-pancreas ratio was seen in the duct-tumor model, which also exhibited the most favorable tumor-to-tissue ratio when compared with kidney, liver, and muscle. Favorable ratios were most pronounced at 6 and 24 hr after injection. These studies provide impetus for the use of 5-TDG as a model compound for the synthesis of potentially useful agents for clinical detection of pancreatic tumors.
- Research Organization:
- Hahnemann Medical Coll., Philadelphia, PA
- OSTI ID:
- 5760059
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:7; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
GLUCOSE
HAMSTERS
HEXOSES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID SCINTILLATION DETECTORS
LIVER
MAMMALS
MEASURING INSTRUMENTS
MONOSACCHARIDES
MUSCLES
NEOPLASMS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
RADIATION DETECTORS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
SACCHARIDES
SCINTILLATION COUNTERS
SULFUR 35
SULFUR ISOTOPES
UPTAKE
VERTEBRATES
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
GLUCOSE
HAMSTERS
HEXOSES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID SCINTILLATION DETECTORS
LIVER
MAMMALS
MEASURING INSTRUMENTS
MONOSACCHARIDES
MUSCLES
NEOPLASMS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
RADIATION DETECTORS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
SACCHARIDES
SCINTILLATION COUNTERS
SULFUR 35
SULFUR ISOTOPES
UPTAKE
VERTEBRATES