Synthesis of S-(3-aminobutyl)isothiourea and its heterocyclic derivative and radioprotective effect of these compounds
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6465492
The authors examine a method for the synthesis of S-(3-aminobutyl)isothiourea dihydrobromide and its cyclization product, 2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazine. The yield and properties of the synthesized compounds are presented. The toxicity and radioprotective activity of the compounds were studied on mice. The effect of prophylactic administration of these compounds on the hemopoietic system of irradiated animals was also studied. Values are given for LD/sub 16/, LD/sub 50/, and LD/sub 84/ used in the determination of toxicity of the preparations, and in studying the antiradiation activity, the mice were subjected to /sup 60/Co gamma-rays.
- Research Organization:
- N.K. Kol'tsova Institute of Developmental Biology, Moscow (USSR)
- OSTI ID:
- 6465492
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:3; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Synthesis of thiocarbamide derivatives of. beta. -alanine and aminalon and study of their antiradiation action
Comparative study of the effects of heterocyclic derivatives of amino alkyl isothiourea on radiosensitivity of the animal organism and cells
Investigation of effects of 2-ADT (2-amino-5,6-dihydro-4H-1,3-thiazine) on hemopoietic organ reaction to radiation
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Pharmaceut. Chem. J.; (United States)
·
OSTI ID:6459937
Comparative study of the effects of heterocyclic derivatives of amino alkyl isothiourea on radiosensitivity of the animal organism and cells
Journal Article
·
Sat Mar 31 23:00:00 EST 1979
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5458388
Investigation of effects of 2-ADT (2-amino-5,6-dihydro-4H-1,3-thiazine) on hemopoietic organ reaction to radiation
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5462648
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
CARBONIC ACID DERIVATIVES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MATERIALS TESTING
MICE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SPLEEN
SURVIVAL CURVES
SYNTHESIS
TESTING
THIOUREAS
TISSUES
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
CARBONIC ACID DERIVATIVES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MATERIALS TESTING
MICE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SPLEEN
SURVIVAL CURVES
SYNTHESIS
TESTING
THIOUREAS
TISSUES
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION