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Comparative study of the effects of heterocyclic derivatives of amino alkyl isothiourea on radiosensitivity of the animal organism and cells

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5458388
; ; ; ; ; ;
Previous experiments on animals revealed that heterocyclic derivatives of amino alkyl isothiourea (AAIT) are among the most effective radioprotective agents. Among these compounds, the following have high and prolonged radioprotective activity: 2-amino-5,6-dihydro-1,3-thiazine (2-ADT); 2-amino-2-thiazoline (2-AT); and 5-methyl-2-amino-2-thiazoline (5-MAT). Heterocyclic compounds were found to be quite stable in the organism. The mechanism of radioprotective action of this group of compounds has not yet been identified; as shown by polarographic studies, they do not have an appreciable effect on oxygenation of tissues and they do not alter the thiol content of tissues. This prompted the question of whether the radioprotective effect of these compounds is related to their direct action on the cellular elements of radiosensitive systems of the organism. This study pursued the objective of determining whether heterocyclic derivatives of AAIT are capable of lowering radiosensitivity of bone marrow cells in vitro and in situ.
Research Organization:
Inst. of Developmental Biology, Moscow, USSR
OSTI ID:
5458388
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:5; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
AMINES
ANIMAL CELLS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BONE MARROW CELLS
CARBONIC ACID DERIVATIVES
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
MAMMALS
MICE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
TABLES
THIAZOLES
THIOUREAS
VERTEBRATES
X RADIATION