Synthesis of thiocarbamide derivatives of. beta. -alanine and aminalon and study of their antiradiation action
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6459937
The authors have synthesized the carboxyl derivatives of S-(2-Amino-ethyl)isothiourea (AET) and S-(3-Aminopropyl)isothiourea (3-APT), the dihydrobromides of S-(1-carboxy-2-aminoethyl)- and S-(1-carboxy-3-aminopropyl)isothioureas, and studied their toxicity and antiradiation effectiveness. Their work is based on data for the high radiation-protective activity of the corresponding aminoalkylisothioureas and on the fact that the introduction of the carboxylic group into the molecule influences the pharmacological properties of a compound. The starting compound for the preparation of S(1-carboxy-2-aminoethyl)isothiourea was beta-alanine. Mice were used in the investigations and in determining the toxicity of the compounds, the amounts of LD/sub 16/, LD/sub 50/, and LD/sub 84/ are given. In studying the anti-radiation activity, the mice were subjected to the action of /sup 60/Co-gamma rays.
- Research Organization:
- M.V. Lomonosov Moscow State Univ. (USSR)
- OSTI ID:
- 6459937
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:3; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALANINE-BETA
ALANINES
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MATERIALS TESTING
METABOLISM
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
SYNTHESIS
TESTING
THIOUREAS
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALANINE-BETA
ALANINES
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MATERIALS TESTING
METABOLISM
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
SYNTHESIS
TESTING
THIOUREAS
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION