Potentiation of radioprotective effects of norepinephrine and other protective agents by various beta-adrenolytic agents. [Mice]
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5457567
Different ..beta..-adrenolytic agents, both universal and selective ..beta../sub 1/ and ..beta../sub 2/, potentiate the radioprotective effect of norepinephrine to an equal extent. Beta-adrenolytic agents also potentiate the radioprotective effects of five other protective agents: direct (mezaton (neosynephrine), fetanol) and indirect (tyramine, 0-methyltyramine), sympathomimetic agents and AET. This confirms the hypothesis that there is an antiprotective effect in the complex action of catecholamines and other protective agents, which is expressed via ..beta..-adreno-receptors. It is desirable to use ..beta..-adrenolytic agents in combinations with various radioprotective agents.
- Research Organization:
- Krasnoyarsk Medical Inst., USSR
- OSTI ID:
- 5457567
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:5; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AET
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
HORMONES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL IRRADIATION
MAMMALS
MICE
NORADRENALINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
STEROID HORMONES
SURVIVAL TIME
SYMPATHOLYTICS
SYMPATHOMIMETICS
SYNERGISM
THIOUREAS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AET
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
HORMONES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL IRRADIATION
MAMMALS
MICE
NORADRENALINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
STEROID HORMONES
SURVIVAL TIME
SYMPATHOLYTICS
SYMPATHOMIMETICS
SYNERGISM
THIOUREAS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION