Alterations in CaS -dependent and CaS -independent release of catecholamines in preparations of rat brain produced by ethanol treatment in vivo
Journal Article
·
· Alcohol; (United States)
OSTI ID:6179367
Compared to preparations from control animals, superfused striatal slice preparations from brains of rats treated chronically with ethanol released a significantly greater fraction of stored (TH) dopamine on depolarisation in 40 mM K . Similarly, the electrically-evoked release of (TH)-norepinephrine from cortical slices and of (TH)-dopamine from striatal slices is also increased, although with this mechanism of depolarisation the change is significant only in the case of (TH) norepinephrine release. In contrast to this tendency to enhancement of CaS -dependent depolarisation-induced release, a reduced fraction of stored (TH)-catecholamines was released from these preparations by the indirect sympathomimetics tyramine and (+)-amphetamine. The catecholamine release induced by these indirect sympathomimetics is largely independent of external CaS and the results are interpreted as suggesting that chronic alcohol treatment changes the distribution of catecholamine neurotransmitters between storage pools in the nerve terminal which do or do not require CaS entry for release.
- Research Organization:
- Kings College, London, England
- OSTI ID:
- 6179367
- Journal Information:
- Alcohol; (United States), Journal Name: Alcohol; (United States) Vol. 1; ISSN ALCOE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALCOHOLS
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMINES
AMPHETAMINES
ANALEPTICS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CALCIUM COMPOUNDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC EXPOSURE
DOPAMINE
DRUGS
ETHANOL
HORMONES
HYDROXY COMPOUNDS
IN VITRO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PHARMACOLOGY
PHENOLS
POLYPHENOLS
POTASSIUM COMPOUNDS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TYRAMINE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALCOHOLS
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMINES
AMPHETAMINES
ANALEPTICS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CALCIUM COMPOUNDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC EXPOSURE
DOPAMINE
DRUGS
ETHANOL
HORMONES
HYDROXY COMPOUNDS
IN VITRO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PHARMACOLOGY
PHENOLS
POLYPHENOLS
POTASSIUM COMPOUNDS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TYRAMINE
VERTEBRATES