Pyrethroid insecticides evoke neurotransmitter release from rabbit striatal slices
The effects of the synthetic pyrethroid insecticide fenvalerate ((R,S)-alpha-cyano-3-phenoxybenzyl(R,S)-2-(4-chlorophenyl)-3- methylbutyrate) on neurotransmitter release in rabbit brain slices were investigated. Fenvalerate evoked a calcium-dependent release of (/sup 3/H)dopamine and (/sup 3/H)acetylcholine from rabbit striatal slices that was concentration-dependent and specific for the toxic stereoisomer of the insecticide. The release of (/sup 3/H)dopamine and (/sup 3/H)acetylcholine by fenvalerate was modulated by D2 dopamine receptor activation and antagonized completely by the sodium channel blocker, tetrodotoxin. These findings are consistent with an action of fenvalerate on the voltage-dependent sodium channels of the presynaptic membrane resulting in membrane depolarization, and the release of dopamine and acetylcholine by a calcium-dependent exocytotic process. In contrast to results obtained in striatal slices, fenvalerate did not elicit the release of (/sup 3/H)norepinephrine or (/sup 3/H)acetylcholine from rabbit hippocampal slices indicative of regional differences in sensitivity to type II pyrethroid actions.
- Research Organization:
- Northwestern Univ. Medical School, Chicago, IL (USA)
- OSTI ID:
- 7040322
- Journal Information:
- J. Pharmacol. Exp. Ther.; (United States), Vol. 246:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na{sub v}1.8 sodium channels expressed in Xenopus oocytes
Effect of in vitro inorganic lead on dopamine release from superfused rat striatal synaptosomes
Related Subjects
ACETYLCHOLINE
SECRETION
DOPAMINE
INSECTICIDES
BIOLOGICAL EFFECTS
CALCIUM
CELL MEMBRANES
HIPPOCAMPUS
IN VITRO
NERVE CELLS
RABBITS
RECEPTORS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALKALINE EARTH METALS
AMINES
AMMONIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
DRUGS
ELEMENTS
ESTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
METALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PESTICIDES
PHENOLS
POLYPHENOLS
PROTEINS
QUATERNARY COMPOUNDS
SOMATIC CELLS
SYMPATHOMIMETICS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques