Carrier-free $sup 11$C-labeled catecholamines in nuclear medicine and biochemical research
Conference
·
OSTI ID:4391505
The catecholamines, dopamine, norepinephrine, and epinephrine, are synthesized and secreted by tissues such as brain, sympathetic nerve endings, and chromaffin cells. Dopamine and norepinephrine are primarily neurotransmitters while epinephrine functions mainly as a hormone. The biosynthesis of the catecholamines from tyrosine is reviewed. Abnormalities in the quantities and metabolism of these compounds are associated with many pathological conditions such as hypertension, Parkinsonism, and chromaffin tissue tumors. Rapid synthetic methods (for the preparation off)/sup 11/C-labeled catecholamines have been developed. The potential use of these labeled catecholamines as scanning agents for the adrenal glands and heart myocardium was evaluated in dogs. (CH)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y. (USA)
- NSA Number:
- NSA-29-010500
- OSTI ID:
- 4391505
- Report Number(s):
- BNL--18379; CONF-740203--2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
*ADRENAL GLANDS-- RADIOISOTOPE SCANNING
*CARBON 11-- TRACER TECHNIQUES
*MYOCARDIUM-- RADIOISOTOPE SCANNING
ADRENALINE
DIAGNOSTIC TECHNIQUES
DOGS
DOPAMINE
HEART
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
NORADRENALINE
NUCLEAR MEDICINE
PATIENTS
RADIOCHEMISTRY
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
TESTING
*CARBON 11-- TRACER TECHNIQUES
*MYOCARDIUM-- RADIOISOTOPE SCANNING
ADRENALINE
DIAGNOSTIC TECHNIQUES
DOGS
DOPAMINE
HEART
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
NORADRENALINE
NUCLEAR MEDICINE
PATIENTS
RADIOCHEMISTRY
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
TESTING