Modification by adrenolytic agents of radioprotective and postradiation effects of phenylephrine hydrochloride in experiments on cell cultures
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5537241
In concentrations of 10-/sup 6/-10/sup -5/ M, mezaton (phenylephrine hydrochloride) has a distinct radioprotective and postradiation effect on cells in an SOC (cynomolgus monkey heart) culture. The radioprotective effect is manifested by an increase in dose (D/sub 0/) and extrapolation number (n), and the postradiation effect, by an increase only in n and D/sub q/. The ..beta..-adrenolytic agent anaprilin (inderal) enhances both effects of mezaton, while the ..cap alpha..-adrenolytic agent, tropaphen eliminates both. This confirms the fact that the radioprotective action of adrenomimetics and modification thereof by adrenolytics can be expressed on the cellular level.
- OSTI ID:
- 5537241
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:2; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Potentiation of radioprotective effects of norepinephrine and other protective agents by various beta-adrenolytic agents. [Mice]
Radioprotective efficacy of synthetic porphyrins in experiments on cell cultures
Radioprotective properties of hypoxia after administration of antihypoxic agents. [Mice, rats, dogs, gamma radiation]
Journal Article
·
Sat Mar 31 23:00:00 EST 1979
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5457567
Radioprotective efficacy of synthetic porphyrins in experiments on cell cultures
Journal Article
·
Mon Oct 01 00:00:00 EDT 1979
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5663386
Radioprotective properties of hypoxia after administration of antihypoxic agents. [Mice, rats, dogs, gamma radiation]
Journal Article
·
Fri Dec 31 23:00:00 EST 1976
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:7300323
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ADRENALINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CELL CULTURES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
HEART
HORMONES
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MONKEYS
NUMERICAL DATA
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
STEROID HORMONES
SYMPATHOLYTICS
SYMPATHOMIMETICS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ADRENALINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CELL CULTURES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
HEART
HORMONES
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MONKEYS
NUMERICAL DATA
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
STEROID HORMONES
SYMPATHOLYTICS
SYMPATHOMIMETICS
VERTEBRATES
X RADIATION