Effect of hydrocortisone on radiosensitivity of hemopoietic stem cells. [. gamma. rays; mice; bone marrow; spleen]

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5457476

Shvets, V N

Studies were made of the direction of differentiation and radiosensitivity of CFU (colony-forming units) of bone marrow and spleen for 1 month after single injection of 5 mg hydrocortisone (HC) per mouse. It was found that there was a sharp change in direction of differentiation of CFU from different sources. Bone marrow CFU enhanced erythropoiesis and CFU of the spleen enhanced myelopoiesis, which is not inherent in the same CFU of normal mice. Determination of radiosensitivity of CFU from different sources according to the spleen colony test failed to demonstrate any differences in value of D/sub 0/ and extrapolation number, whereas substantial changes in radiosensitivity were demonstrated in the bone marrow colony test. Radiosensitivity of marrow CFU diminished while that of the spleen increased, as compared to the control. It is assumed that these phenomena are due to redistribution of T lymphocytes in response to HC.

• OSTI ID: 5457476
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:4; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CELL DIFFERENTIATION
CESIUM 137
CESIUM ISOTOPES
CFU
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
GLUCOCORTICOIDS
HORMONES
HYDROCORTISONE
HYDROXY COMPOUNDS
IN VITRO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
KETONES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PREGNANES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
STEM CELLS
STEROID HORMONES
STEROIDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES