Radiosensitivity of hemopoietic stem cells cloned in bone marrow and spleen
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5590776
It has been demonstrated that the population of mouse bone marrow stem cells is heterogeneous with regard to radiosensitivity. The survival of about 55% CFU (colony-forming units) is described as an exponential function of radiation dose (D/sub 0/ = 9 rad). The dose-effect curve for the resistant part of the population (D/sub 0/ = 180 rad) is sigmoidal, with D/sub q/ = 130 rad. It is assumed that radiosensitive CFU represent the primary committed fraction of semistem cells, while the radioresistant ones are referable to the pool of pluripotent stem cells. The heterogeneity of the CFU population is confirmed with the use of various modifications of irradiation and in interaction of CFU with T lymphocytes.
- OSTI ID:
- 5590776
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:1; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CELL CULTURES
CFU
CLONE CELLS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CELL CULTURES
CFU
CLONE CELLS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES