In vivo radiosensitivity and recovery pattern of the hematopoietic precursor cells and stem cells in mouse bone marrow
Journal Article
·
· Exp. Hematol.; (United States)
OSTI ID:6068671
Survival curves were determined for colony-forming hematopoietic stem cells (CFU-Mix and CFU-S10) as well as precursor cells (CFU-E, CFU-C, CFU-F, and BFU-E) in bone marrow of the mouse at various times up to 4 weeks after whole-body irradiation (1.5 or 3.0 Gy) in order to elucidate in vivo radiosensitivity and recovery patterns. These measurements represented the first attempts to examine CFU-Mix simultaneously with the other cell populations. CFU-E (D0 = 53 rad) and BFU-E (D0 = 68 rad) were the most radiosensitive. CFU-S10 (D0 = 81 rad) had intermediate radiosensitivity. CFU-Mix (D0 = 144 rad) and CFU-C (D0 = 157 rad) were relatively radioresistant. CFU-F (D0 = 257 rad) was the most radioresistant. The precursor and stem cells could be classified into three groups based on the recovery pattern. The first group, consisting of CFU-Mix, BFU-E, and CFU-S10, showed very slow recovery and did not reach normal levels even after day 28. CFU-E, the second group, showed the most severe depletion immediately after irradiation, and recovered most quickly with an overshoot at day 5. CFU-C and CFU-F cells, forming the third group, decreased more gradually and slightly, and recovered to the normal level after a transient rise by day 10-14.
- Research Organization:
- National Institute of Radiological Sciences, Chiba, Japan
- OSTI ID:
- 6068671
- Journal Information:
- Exp. Hematol.; (United States), Journal Name: Exp. Hematol.; (United States) Vol. 15:8; ISSN EXHMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
DOSES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IN VIVO
IRRADIATION
MAMMALS
MICE
ORGANS
PRECURSOR
RADIATION DOSES
RADIOSENSITIVITY
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
DOSES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IN VIVO
IRRADIATION
MAMMALS
MICE
ORGANS
PRECURSOR
RADIATION DOSES
RADIOSENSITIVITY
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION