The effects of x-irradiation on hematopoietic stem cell compartments in the mouse

Journal Article · Thu Aug 01 04:00:00 EDT 1991 · Experimental Hematology (Lawrence, Kansas); (United States)

OSTI ID:5018796

Meijne, E I; Ploemacher, R E; Vos, O; David, J A; Huiskamp, R ^[1]

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1. Netherlands Energy Research Foundation, Petten (Netherlands)

The sensitivity for x-irradiation of a series of hematopoietic stem cell populations has been determined. The most primitive cells identified, cells with marrow-repopulating ability (MRA), showed the highest degree of radioresistance. These MRA cells which generate many secondary day-twelve spleen colony-forming units (MRA(CFU-S-12)) or colony-forming units in culture (MRA(CFU-C)) in the marrow of primary recipients had Do values equal to 1.18 and 1.13 Gy, respectively. The more mature CFU-S-12 had intermediate radiosensitivity (Do = 0.94 Gy), whereas the less primitive CFU-S-7 were the most radiosensitive (Do = 0.71 Gy). The in vitro colony-forming precursor cells (CFU-C) showed low radiosensitivity. These data clearly show that the most primitive hematopoietic stem cell measured is less sensitive to ionizing radiation than generally has been assumed on the basis of measurements on CFU-S-7 or CFU-S-12.

• OSTI ID: 5018796
• Journal Information: Experimental Hematology (Lawrence, Kansas); (United States), Journal Name: Experimental Hematology (Lawrence, Kansas); (United States) Vol. 19:7; ISSN EXHMA; ISSN 0301-472X
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
COLONY FORMATION
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
STEM CELLS
TISSUES
VERTEBRATES
X RADIATION