Interaction of lead and high ambient temperatures in the rat

Journal Article · Sun Apr 01 00:00:00 EST 1979 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(79)90114-2· OSTI ID:5456709

Wright, G L; Lessler, M A

The effects of combined exposure to an environmental temperature of 23/sup 0/C or 33/sup 0/C, and 1% lead acetate in the diet on food intake, body weight, tissue lead content, and thermoregulation were examined in rats. Lead ingestion at an environmental temperature at 33/sup 0/C resulted in reduced food intake and a decrease in body weight in a manner suggesting that the effects of the two agents were additive. Continuous exposure to 33/sup 0/C produced a significant enhancement of the thermal response of rats subjected to a temperature of 44/sup 0/C, which was not modified by lead exposure. The lead content of the adrenal glands, spleen, and bone marrow from lead-fed rats housed at 33/sup 0/C was significantly increased over that of 23/sup 0/C maintained animals. Liver, blood, skeletal muscle, and brain lead contents were similar to values obtained for rats receiving lead at 23/sup 0/C.

• Research Organization: Ohio State Univ. College of Medicine, Columbus
• OSTI ID: 5456709
• Journal Information: Environ. Res.; (United States), Vol. 18:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMBIENT TEMPERATURE
TEMPERATURE EFFECTS
BODY COMPOSITION
BIOLOGICAL EFFECTS
DIET
LEAD
TOXICITY
RATS
THERMOREGULATION
WEIGHT
HIGH TEMPERATURE
INGESTION
TISSUE DISTRIBUTION
ANIMALS
CONTROL
DISTRIBUTION
ELEMENTS
INTAKE
MAMMALS
METALS
RODENTS
TEMPERATURE CONTROL
VERTEBRATES
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