Autoradiographic distribution of /sup 14/C-labeled 3H-imidazo(4,5-f)quinoline-2-amines in mice

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Cancer Res.; (United States)

OSTI ID:5478906

Bergman, K

The highly mutagenic heterocyclic amines, 2-amino-3-methylimidazo(4,5-f)quinoline (IQ) and 2-amino-3,4-dimethylimidazo(4,5-f)quinoline (MeIQ), are formed during heating of protein-rich foods. In order to gain information about the distribution and fate of IQ and MeIQ in vivo, a whole-body autoradiographic study of i.v.-injected /sup 14/C-labeled IQ and MeIQ has been performed in male NMRI, pregnant NMRI, and female C3H mice. IQ and MeIQ showed similar distribution patterns. At short survival times, the autoradiograms were characterized by an accumulation of radioactivity in metabolic and excretory organs (liver, kidney, bile, urine, gastric and intestinal contents, salivary glands, nasal mucosa, and Harder's gland), as well as in lymphomyeloid tissues (bone marrow, thymus, spleen and lymph nodes) and in endocrine and reproductive tissues (adrenal medulla, pancreatic islets, thyroid, hypophysis, testis, epididymis, seminal vesicles, ampulla, and prostate). The liver and kidney cortex were identified as sites of retention of nonextractable radioactivity. IQ and MeIQ showed a strong affinity for melanin. IQ and MeIQ passed the placenta, but no radioactivity was retained in fetal tissues. The results pinpoint the liver as a site of IQ- and MeIQ-mediated toxicity. Future studies of IQ and MeIQ may be guided by and clarify the role of other tissue localizations in the toxicity of IQ and MeIQ.

• Research Organization: National Food Administration, Uppsala, Sweden
• OSTI ID: 5478906
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 45:3; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
AUTORADIOGRAPHY
AZAARENES
AZINES
BODY
CARBON 14 COMPOUNDS
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
FOOD
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
KIDNEYS
LABELLED COMPOUNDS
LIVER
LYMPHATIC SYSTEM
MAMMALS
MELANIN
METABOLISM
MICE
MUTAGENS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PREGNANCY
PYRIDINES
QUINOLINES
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES