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Radiofrequency radiation alters the immune system. II. Modulation of in vivo lymphocyte circulation

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575259· OSTI ID:5023345
In vivo lymphocyte circulation was significantly altered in mice exposed to whole-body radiofrequency radiation (RFR). In vivo lymphocyte circulation was followed by quantitating activity of sodium chromate-51-labeled lymphocytes in the lung, spleen, liver, and bone marrow of animals at different times after iv spleen lymphocyte injection. Immediately after cell injection, animals were exposed to 2.6-GHz RFR (CW) at 25 or 5 mW/cm/sup 2/ (3.8 W/kg) for 1 h. At 1,6, and 24 h aftr lymphocyte injection target organs were removed, weighed, and counted. Sham RFR, warm-air, and steroid-treated groups were included as controls. Hyperthermic RFR exposure (25 mW/cm/sup 2/, 2.0/sup 0/C increase in core temperature) led to a 37% reduction in lymphocytes leaving the lung to migrate into the spleen. In addition, a threefold increse in spleen lymphocytes entering the bone marrow occurred. Significantly, this pattern was also observed in the steroid-treated group; nonthermogenic RFR exposure (5 mWcm/sup 2/) and warm-air exposures did not lead to altered lymphocyte traffic. These results support the idea that steroid release associated with thermal stress and the process of thermoregulation is a significant operatnt factor responsible for RFR effects on the immune system.
Research Organization:
Air Force School of Aerospace Medicine, Brooks Air Force Base, San Antonio, TX
OSTI ID:
5023345
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:1; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IMMUNITY
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LIVER
LUNGS
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOWAVE RADIATION
RESPIRATORY SYSTEM
RF SYSTEMS
RODENTS
SOMATIC CELLS
SPLEEN
TISSUES
VERTEBRATES