MORPHOLOGICAL CHANGES IN THE BLOOD AND BONE MARROW OF WHITE RATS OF DIFFERENT AGES, EXPOSED TO SUBLETHAL DOSES OF $gamma$-RADIATION (IN ANIMALS KEPT ON DIFFERENT DIETS)

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Tr. Inst. Eksperim. i Klinich. Med., Akad. Nauk Latv. SSR

OSTI ID:4685730

Prane, L Yu

Young rats (37 animals weighing 82 to 90 g each) and 113 adult or ageiog rats (weighing 187 to 350 g each) were used for the experiment. After an investigation of 24 animals in each group to establish the initial condition of the peripheral blood and the bone marrow, one half of each group was kept on an adequate diet aod the other half on a diet deficient in proteins and vitamins. After a preliminary period of 1 to 2 months the animals were exposed to gamma radiation in a dose of 700 r, emitted by the GUT Co-400-1 apparatus. The animals were killed 36 hours, 5, 10, and 20 days after exposure. The peripheral blood and the myelogram were then investigated. In both young and adult (ageing) animals, blood changes characteristic of acute radiation sickness could be observed. In young animals kept on an adequate diet, however, these changes were less naarked than in young animals kept on a deficient diet. No such difference could be found between the two groups of adult rats kept on different diets. A diet deficient in proteins and vitamins delayed the regeneration of the blood picture in both age groups. Here too, however, the young animals seemed to recover more rapidly on an adequate diet. These differences are explained by the greater reactivity of young animals. (OTS) diet showed a slight increase. gamma radiation had no appreciable effect upon the content of riboflavioe and vitamin B/sub 12/. The content of ascorbic acid of the liver and the adrenal glands increased after exposure to radiation, independently of the diet. An increase in the globin content of the blood could be observed only in animals kept on a full diet. In these animals, iron accumulated to a greater degree in the spleen and the bone marrow. As a whole, this investigation showed that biochemical changes are more marked in animals kept on a full diet, a fact which is explained by the greater activity of the biochemical processes. (OTS)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030435
• OSTI ID: 4685730
• Journal Information: Tr. Inst. Eksperim. i Klinich. Med., Akad. Nauk Latv. SSR, Journal Name: Tr. Inst. Eksperim. i Klinich. Med., Akad. Nauk Latv. SSR Vol. Vol: 8
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
DIET
GAMMA RADIATION
GAMMA SOURCES
PROTEINS
RADIATION DOSES
RADIATION SICKNESS
RATS
REGENERATION
VARIATIONS
VITAMINS
WEIGHT