STRUCTURAL CHANGES CAUSED BY $gamma$-RADIATION IN THE LYMPHOID TISSUE OF EXPERIMENTAL ANIMALS MAINTAINED ON DIFFERENT DIETS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Tr. Inst. Eksperim. i Klinich. Med., Akad. Nauk Latv. SSR

OSTI ID:4704729

Demidova, V K

Adult male white rats (162 animals each weighing 187 to 350 g) and 47 young male rats (weighing 80 to 220 g) were exposed to total-body gamma - irradiation, using the GUT Co400-1 apparatus. The young rats (previously kept for 4 weeks on wheat biscuits) were then divided into 2 groups. In the first group 2 g and in the second group 6 g of a protein vitamin complex were added to each daily food ration. After 4 weeks on this diet these young animals were then exposed to 500 r. The adult rats were kept for 4 weeks on the usual laboratory diet and were also divided into 2 groups; the first group was kept on wheat biscuits alone for 4 weeks, and the second on biscuits containing 35% of a protein-vitamin complex. After 4 weeks on this diet the adult rats were exposed to 700 r. Both young and adult animals were killed 36 hours, 5, 10, 20, and 50 days after exposure. Paraffin sections of the lymphoid tissue in the lymph nodes, the spleen, the thymus, and the liver were stained with hematoxylin and eosin, and by van Gieson's and Maximov's stains. In the spleen, the lymph nodes, and the thymus, a marked decrease in the number of lymphocytes could be observed within 36 hr after exposure. No mitoses could be seen and the nuclei occasionally showed signs of fragmentation. Hyperplasia of the reticular apparatus developed. Severity of the lesions showed no relation to the diet. In animals kept on a deficient diet, however, the onset of regeneration was delayed. In the liver, however, the picture was different. Here the initial lesions were more profound in animals kept on a deficient diet, whereas the rate of regeneration was the same in both groups. (OTS)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030431
• OSTI ID: 4704729
• Journal Information: Tr. Inst. Eksperim. i Klinich. Med., Akad. Nauk Latv. SSR, Journal Name: Tr. Inst. Eksperim. i Klinich. Med., Akad. Nauk Latv. SSR Vol. Vol: 8
• Country of Publication: Country unknown/Code not available
• Language: English

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