A quantitative in vitro study of fibroblast and endothelial cell migration in response to serum and wound fluid
Journal Article
·
· J. Surg. Res.; (United States)
Chemoattractant activity for irradiated and nonirradiated rabbit skin fibroblast and bovine aortic arch endothelial cells was assayed in rabbit wound fluid and sera using a modification of the agarose well method originally described for polymorphonuclear leukocytes. Both serum and wound fluid contained chemoattractants for fibroblasts and endothelial cells. Fibroblast migration was decreased by 70 to 80% when the serum or wound fluid was heated to 56 degrees C for 30 min while endothelial cell migration was reduced by 50 to 60%. Platelet-poor plasma-derived serum had no directive effect on the migration of either cell type.
- Research Organization:
- Department of Surgery, School of Medicine, University of California, San Francisco
- OSTI ID:
- 5427625
- Journal Information:
- J. Surg. Res.; (United States), Journal Name: J. Surg. Res.; (United States) Vol. 35:3; ISSN JSGRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CATTLE
CONNECTIVE TISSUE CELLS
COWS
DOMESTIC ANIMALS
FIBROBLASTS
INJURIES
LEUKOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
ORGANS
RABBITS
RADIATION EFFECTS
RUMINANTS
SKIN
SOMATIC CELLS
VERTEBRATES
WOUNDS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CATTLE
CONNECTIVE TISSUE CELLS
COWS
DOMESTIC ANIMALS
FIBROBLASTS
INJURIES
LEUKOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
ORGANS
RABBITS
RADIATION EFFECTS
RUMINANTS
SKIN
SOMATIC CELLS
VERTEBRATES
WOUNDS