Supersensitivity of GABAergic systems induced within rat substantia nigra and globus pallidus by haloperidol
Thesis/Dissertation
·
OSTI ID:5406896
The supersensitivity was demonstrated by an increase in the responsiveness of individual neurons within these brain regions to microiontophoretically-applied GABA and by an up regulation of GABA binding sites. Rates received haloperidol for 30 days in their feed and were then withdrawn from treatment for 48 hrs. {sup 3}H-GABA binding was found to be significantly elevated with the SN{sub R} (55%) and GP (42%). Scatchard analysis of {sup 3}H-muscimol binding isotherms indicated that the number (B{sub max}) of high affinity binding sites within the GP was significantly increased (32%); within the SN{sub R}, significant increases were detected in the B{sub max} of both high (23%) and low (58%) affinity {sup 3}H-muscimol binding sites. After CHAL treatment, signs of dopaminergic supersensitivity within the basal ganglia were also observed. Spontaneous locomotor activity and apomorphine-induced stereotyped behavior were increased and specific {sup 3}H-spiroperidol binding was elevated within the striatum (60%) and GP (236%).
- Research Organization:
- Texas Univ., San Antonio, TX (USA)
- OSTI ID:
- 5406896
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMAL CELLS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MEMBRANE PROTEINS
NERVE CELLS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
PSYCHOTROPIC DRUGS
REACTION KINETICS
RECEPTORS
SENSITIVITY
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMAL CELLS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MEMBRANE PROTEINS
NERVE CELLS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
PSYCHOTROPIC DRUGS
REACTION KINETICS
RECEPTORS
SENSITIVITY
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS