Different effects of long-term haloperidol administration on GABA/sub A/ and benzodiazepine receptors in various parts of the brain
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The data described in this paper are evidence that long-term administration of haloperidol has an opposite effect on the density of GABA/sub A/ and benzodiazepine receptors in the fore- and hindbrain. These changes are reflected at the molecular level as reversal of behavioral effect of the GABA/sub A/ agonist muscimol and the benzodiazepine agonist Ro15-1788. By means of parallel behavioral tests, binding of /sup 3/H-muscimol in the fore- and hindbrain of rats was investigated in experiments in vitro. /sup 3/H-flunitrazepam binding experiments were carried out in vivo on mice. Parallel with reversal of the behavioral effects of muscimol and Ro15-1788, the number of binding sites both for /sup 3/H-muscimol and for /sup 3/H-flunitrazepam in the forebrain was reduced; in the hindbrain the opposite process took place.
- Research Organization:
- Tartu Univ., USSR
- OSTI ID:
- 5784859
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:4; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550101* -- Behavioral Biology-- Tracer Techniques
550301 -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC INTAKE
DRUGS
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MENTAL DISORDERS
MICE
MORPHOLOGICAL CHANGES
NERVE CELLS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
QUANTITY RATIO
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULTRASTRUCTURAL CHANGES
VERTEBRATES
550301 -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC INTAKE
DRUGS
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MENTAL DISORDERS
MICE
MORPHOLOGICAL CHANGES
NERVE CELLS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
QUANTITY RATIO
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULTRASTRUCTURAL CHANGES
VERTEBRATES