Enhanced striatial /sup 3/H-spiroperidol binding induced by chronic haloperidol treatment inhibited by peptides administered during the withdrawal phase
Journal Article
·
· Life Sci.; (United States)
Chronic intragastric administration of haloperidol (1.5 mg/kg/day) for 21 days followed by a 3-day withdrawal period resulted in the development of enhanced locomotor activity response to apomorphine, and an increase in the number of binding sites for /sup 3/H-spiroperidol in the striatal membranes of the rat brain. Subcutaneous administration of Pro-Leu-Gly-NH/sub 2/ or cyclo-(Leu-Gly) in doses of 2 mg/kg/day given for 3-days after termination of haloperidol treatment inhibited the enhanced response to apomorphine, as well as the increases in the number of /sup 3/H-spiroperidol binding sites in the striatum. If indeed, the supersensitivity of striatal dopamine receptors is one of the mechanisms in the development of tardive dyskinesia symptoms, the present results suggest that the above peptides may be helpful in ameliorating some of the symptoms of tardive dyskinesia induced by neuroleptic drugs. 31 references, 3 figures.
- Research Organization:
- Univ. of Illinois, Chicago
- OSTI ID:
- 6007706
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 34:9; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Thesis/Dissertation
·
Tue Dec 31 23:00:00 EST 1985
·
OSTI ID:5406896
Comparison in animal models of /sup 18/F-spiroperidol and /sup 18/F-haloperidol: potential agents for imaging the dopamine receptor
Journal Article
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Sat Oct 01 00:00:00 EDT 1983
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·
OSTI ID:5217123
Differences in the time course of haloperidol-induced up-regulation of rat striatal and mesolimbic dopamine receptors
Journal Article
·
Thu Dec 31 23:00:00 EST 1987
· Life Sci.; (United States)
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OSTI ID:6292561
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMISTRY
CHRONIC EXPOSURE
DOPAMINE
DRUGS
HOMOGENATES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PHENOLS
POLYPHENOLS
PROTEINS
PSYCHOTROPIC DRUGS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMISTRY
CHRONIC EXPOSURE
DOPAMINE
DRUGS
HOMOGENATES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PHENOLS
POLYPHENOLS
PROTEINS
PSYCHOTROPIC DRUGS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES