Comparison in animal models of /sup 18/F-spiroperidol and /sup 18/F-haloperidol: potential agents for imaging the dopamine receptor
Journal Article
·
· Life Sci.; (United States)
Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 +/- 1.6 is obtained two hours after administration of the /sup 18/F-spiroperidol. When /sup 18/F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 5217123
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 33:17; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
A comparison of (/sup 18/F)spiroperidol, (/sup 18/F)benperidol and (/sup 18/F) haloperidol kinetics in baboon brain
Neuroleptic binding sites: specific labeling in mice with (/sup 18/F)haloperidol, a potential tracer for positron emission tomography
(/sup 18/F)-N-methylspiroperidol: the radioligand of choice for PETT studies of the dopamine receptor in human brain
Conference
·
Sat Dec 31 23:00:00 EST 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:6779330
Neuroleptic binding sites: specific labeling in mice with (/sup 18/F)haloperidol, a potential tracer for positron emission tomography
Journal Article
·
Sun May 01 00:00:00 EDT 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:5744550
(/sup 18/F)-N-methylspiroperidol: the radioligand of choice for PETT studies of the dopamine receptor in human brain
Journal Article
·
Mon Dec 31 23:00:00 EST 1984
· Life Sci.; (United States)
·
OSTI ID:6940325
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
LIGHT NUCLEI
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
LIGHT NUCLEI
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES