Selenium bioavailability of infant milk diets

Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5392269

Raghib, H; Chan, W Y; Rennert, O M

The effects of age, types of milk diet and chemical forms of SE on its bioavailability were studied using suckling rats as a model. Human milk, bovine milk and infant formula (regular Similac) extrinsically labeled with either (/sup 75/Se) selenite or (/sup 75/Se) selenomethionine were fed by gastric intubation to 8, 10, 15 and 20 (or 30)-day-old rats. Retention of /sup 75/Se in gut free carcass and liver was measured 3 hours after feeding. At any given age the corresponding absorption of /sup 75/Se from the 3 diets was similar except at 15 days of age when significantly more (/sup 75/Se) selenomethionine was absorbed from human milk (83%) than from bovine milk or formula (72%). Much higher amount of (/sup 75/Se) selenomethionine was absorbed by any age group from the 3 milk diets compared to (/sup 75/Se) selenite. An age related change in both (/sup 75/Se) selenite and (/sup 75/Se) selenomethionine absorption was noticed in all 3 diets. Gut free carcass (/sup 75/Se) selenite absorption was 32% in 8-d-old rats and increased to 46% in 20-d-old rats. The corresponding liver /sup 75/Se retention was 7.5 and 19.5%. On the other hand, (/sup 75/Se) selenomethionine retention by the gut free carcass decreased with age from an average of 83% in 8-d-old rats to 72% in 20-d-old rats. The corresponding /sup 75/Se incorporation into the liver increased from 15.5% in 8-d-old rats to 21.9% in 20-d-old rats. It is concluded that twice as much /sup 75/Se) selenite and an age related change in /sup 75/Se absorption was noticed between the 2 chemical forms of Se and between human milk and the other 2 milk diets.

• Research Organization: Univ. of Oklahoma Health Sciences Center, Oklahoma City
• OSTI ID: 5392269
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BODY
BODY FLUIDS
CATTLE
DAYS LIVING RADIOISOTOPES
DIET
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOOD
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MAN
MATERIALS
METABOLISM
MILK
NEONATES
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
RATS
RETENTION
RODENTS
RUMINANTS
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES