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Effect of iron additive to milk on cadmium, mercury, and manganese absorption in rats

Journal Article · · Environ. Res.; (United States)
OSTI ID:6601136
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Six-day-old sucklings and 6-week-old female rats were used in the experiment to estimate whether low iron content of milk is the reason for increased gastrointestinal absorption of metals. The absorption of /sup 115m/Cd, /sup 203/Hg, and /sup 54/Mn was determined by measuring the body retention (whole body, carcass, and gut) 6 days after oral administration. To sucklings radioisotopes were administered by artificial feeding with cow's milk with or without 100 ppM Fe additive. Iron addition had no influence on metal absorption at this age. The same radioisotopes were administered by stomach tube to older animals fed rat's diet or milk with or without 100 ppM Fe additive. Increased iron content of milk decreased the absorption of all metals. For mercury and cadmium most of this effect was due to decreased gut retention and only partly to decreased carcass retention. It is concluded that the high absorption of metals in sucklings is not likely to be due to the low iron content of milk and also that iron does not interact with cadmium, mercury, and manganese in the absorption process at this age.
Research Organization:
Univ. of Zagreb, Yugoslavia
OSTI ID:
6601136
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY FLUIDS
CADMIUM 115
CADMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOOD
GASTROINTESTINAL TRACT
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
IRON
ISOTOPES
MAMMALS
MANGANESE 54
MANGANESE ISOTOPES
MATERIALS
MERCURY 203
MERCURY ISOTOPES
METALS
MILK
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RATS
RODENTS
TOXICITY
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES