Circadian stage dependence in radiation: response of dividing cells in vivo
Journal Article
·
· Prog. Clin. Biol. Res.; (United States)
OSTI ID:5388202
1) When the mouse corneal epithelium wa irradiated with one dose or ionizing radiation, the effect on mitosis varied depending upon the time in the 24-h period when it was irradiated. 2) Release of the radiation-induced mitotic block, as measured by appearance of a recovery wave of mitotic cells, occurred only during the daily increase in mitotic index in the control animals. 3) The entire wave of recovery occurred within the same time as the controls, and no rebound was seen. 4) Mitotic delay was dose-dependent. 5) The results of these experiments emphasize the importance of considering the circadian system when studying cell division in vivo.
- OSTI ID:
- 5388202
- Journal Information:
- Prog. Clin. Biol. Res.; (United States), Journal Name: Prog. Clin. Biol. Res.; (United States) Vol. 59C:00; ISSN PCBRD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CYCLE
CELL DIVISION
DAILY VARIATIONS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EPITHELIUM
IN VIVO
MAMMALS
MICE
MITOSIS
MITOTIC DELAY
MITOTIC INDEX
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RODENTS
TIME DEPENDENCE
TISSUES
VARIATIONS
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CYCLE
CELL DIVISION
DAILY VARIATIONS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EPITHELIUM
IN VIVO
MAMMALS
MICE
MITOSIS
MITOTIC DELAY
MITOTIC INDEX
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RODENTS
TIME DEPENDENCE
TISSUES
VARIATIONS
VERTEBRATES