Influence of the circadian rhythm in cell division on radiation-induced mitotic delay in vivo
Mitotic delay is described as a classical response to radiation; however, circadian rhythmicity in cell division in vivo has not been considered by many authors. The present study investigated the relation between fluctuations reported as mitotic delay and recovery in vivo and circadian oscillations in mitotic index in mouse corneal epithelium. One aspect involved single doses (approximately 600 rad) given to mice at different circadian stages. The normal circadian rhythm in cell division was never obliterated. Inhibition of mitosis was evident but unpredictable, ranging from 6 to 15 hr after irradiation. Recovery was evident only during the daily increase in mitotic index of controls. The classical interpretation of recovery from mitotic delay may be in an in vitro phenomenon not reflecting in vivo responses, which are apparently strongly circadian stage dependent. The second portion of the study demonstrated a dose-response effect on length of mitotic delay and, to a lesser extent, degree of recovery.
- Research Organization:
- Univ. of Arkansas for Medical Sciences, Little Rock
- OSTI ID:
- 5571988
- Journal Information:
- Radiat. Res.; (United States), Vol. 89:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MITOTIC DELAY
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
DAILY VARIATIONS
IN VIVO
MICE
MITOSIS
RADIATION DOSES
ANIMALS
BIOLOGICAL EFFECTS
CELL DIVISION
DOSES
MAMMALS
RADIATION EFFECTS
RECOVERY
RODENTS
VARIATIONS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)