ON THE ROLE OF NUCLEAR DAMAGE IN THE REGENERATION OF IRRADIATED TISSUES

Journal Article · Mon May 01 04:00:00 EDT 1961 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006114551221· OSTI ID:4044583

Shapiro, I M

During interphase, prior to the first post-irradiation mitosis, the preservation of a percentage of cells with chromosomal aberrations (bridges, acentric fragments) takes place in the rat liver and in the corneal epithelium of the mouse. Cells of corneal epithelium with such abberations die in F/sub 1/--F/ sub 3/ or F/sub 1/. The dose-dependence relationship of the percentage of corneal cells with abberations was obtained. Circa 100 per cent of cells had lethal chromosomal rearrangements after being exposed to 2 to 3 kr of x rays. Mitotic activity recovered, but only in part, after x-irradiation with 10 to 30 kr. The formation of giant polyploid cells from irradiated diploid ones was demonstrated. It was calculated that the percentage of cells without bridge and acentric fragments increased two times and the mitotic index 1.5 times after exposure in CO-atmosphere as compared with irradiation in air. The differences of the mitotic index and the percentage of cells with abberations in mouse corneal epithelium were used as a model for these estimations. Hypothermia (21 deg ) during irradiation had no protective effect on the rate of mitotic activity recovery and on the percentage of cells with aberrations. (auth)

• Research Organization: Severztov Inst. of Animal Morphology, Academy of Sciences, Moscow
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-022040
• OSTI ID: 4044583
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AIR
ANIMAL CELLS
BIOLOGY AND MEDICINE
CARBON MONOXIDE
CHROMOSOMES
CYTOLOGY
EYES
IRRADIATION
LIVER
MICE
MITOSIS
RADIATION DOSES
RADIATION PROTECTION
RATS
RECOVERY
REGENERATION
TEMPERATURE
TISSUES
X RADIATION