Gallium scanning in Paget's disease of bone: effect of calcitonin

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.134.2.303· OSTI ID:5371869

Waxman, A D ^[1]; McKee, D; Siemsen, J K; Singer, F R

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1. Cedars-Sinai Medical Center, Los Angeles, CA

Calcitonin has been used in the treatment of Paget's disease of bone, and serum alkaline phosphatase level and 24 hr urinary hydroxyproline excretion have been used to follow therapeutic response. The radionuclide bone scan has been used as a visual indicator; however, there is some uncertainty as to its value in following changes in disease activity. Four patients with both serial technetium phosphate bone scans and serial gallium studies were studied. In each case the beneficial effect of calcitonin was demonstrated more accurately with gallium than with technetium diphosphonate. Since biochemical changes in Paget's disease are believed to be mediated at the cellular level and gallium uptake depends on cellular activity, it is proposed that gallium uptake is more appropriate measure of the activity of Paget's disease than a noncellular marker such as a technetium-containing bone scan agent.

• OSTI ID: 5371869
• Journal Information: Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 134:2; ISSN AJROA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCITONIN
CARBOXYLIC ACID SALTS
CITRATES
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GALLIUM 67
GALLIUM ISOTOPES
HORMONES
HOURS LIVING RADIOISOTOPES
INFLAMMATION
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PEPTIDE HORMONES
PEPTIDES
PHOSPHONATES
POLYPEPTIDES
PROTEINS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SKELETAL DISEASES
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES