Skeletal distribution and biochemical parameters of Paget's disease

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Clin. Orthop. Relat. Res.; (United States)

OSTI ID:6617384

Meunier, P J; Salson, C; Mathieu, L; Chapuy, M C; Delmas, P; Alexandre, C; Charhon, S

Quantitative bone scans were performed with /sup 99m/Tc-EHDP in 170 untreated pagetic patients (93 men, 77 women; mean age, 65.4 years). The distribution of 863 pagetic skeletal locations was analyzed. Bone scans demonstrated 8.3% more pagetic sites than roentgenograms. The extent of Paget's disease was evaluated in each patient by a scintigraphic skeletal index. This index correlated with serum alkaline phosphatase (SAP) and urinary hydroxyproline (HyPro) levels, and also with hypocalcemic acute response to calcitonin. The correlation of SAP with an index of activity (extent index adjusted by uptake ratios) was better than with the nonadjusted index. Only 30.6% of pagetic sites were responsible for clinical symptoms. No correlation was found between age and skeletal index of the disease.

• Research Organization: Faculte Alexis Carrel, Lyon, France
• OSTI ID: 6617384
• Journal Information: Clin. Orthop. Relat. Res.; (United States), Journal Name: Clin. Orthop. Relat. Res.; (United States) Vol. 217; ISSN CORTB
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE PHOSPHATASE
AMINES
AMINO ACIDS
ANTIBODIES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CALCITONIN
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ENZYMES
ESTERASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROLASES
HYDROXY ACIDS
HYDROXYPROLINE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PEPTIDES
PHOSPHATASES
POLYPEPTIDES
PROTEINS
PYRROLES
PYRROLIDINES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SCINTISCANNING
SKELETAL DISEASES
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES