Evaluation of /sup 99m/Tc diphosphonate kinetics and bone scans in patients with Paget's disease before and after calcitonin treatment

Conference · Thu Dec 01 00:00:00 EST 1977 · Radiology; (United States)

OSTI ID:5335170

Waxman, A D; Ducker, S; McKee, D; Siemsen, J K; Singer, F R

Eleven patients with Paget's disease of bone underwent serial total body bone scans before and after therapy with calcitonin. All patients studied showed improvement clinically as well as biochemically. Scan improvement was noted in patients with mild disease. Patients with severe disease showed either no change or only slight improvement on the serial bone scans. The scan was of greatest value in determining the extent of disease, especially in 3 patients in whom biochemical values were normal. A single pulse injection of 50 M.R.C. units of salmon calcitonin produced a significant increase in the blood clearance of /sup 99m/Tc diphosphonate. The mechanism of this effect is not clear from this study.

• Research Organization: Univ. of Southern California Medical Center, Los Angeles
• OSTI ID: 5335170
• Journal Information: Radiology; (United States), Vol. 125:3; Conference: 62. Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, IL, USA, 14 Nov 1976
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE TISSUES
SCINTISCANNING
CALCITONIN
BIOLOGICAL EFFECTS
SKELETAL DISEASES
DIAGNOSIS
TECHNETIUM 99
ISOMERIC NUCLEI
PATIENTS
RADIONUCLIDE KINETICS
THERAPY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HORMONES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics