Gallium-67 citrate localization in osteoclast nuclei of Paget's disease of bone

Journal Article · Wed Jun 01 04:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:6973683

Mills, B G; Masuoka, L S; Graham, Jr, C C; Singer, F R; Waxman, A D

Gallium-67 citrate scintigraphy has been used to indicate the extent of bone involvement in patients with Paget's disease of bone and is an excellent marker in monitoring the effects of specific therapy. Since gallium uptake is dependent on cellular function, autoradiographic techniques can be applied to cells of Paget's lesions to understand better the mechanism of (/sup 67/Ga)citrate uptake. Bone biopsies were obtained from sites of increased uptake using (/sup 67/Ga)citrate scintigraphy in two patients with Paget's disease. In both patients electron microscopic autoradiographs demonstrated a high concentration of silver grains over the nuclei of osteoclasts. The cellular mechanism is unknown but may be related to the known inhibitory effect of calcitonin on osteoclast activity. The association of (/sup 67/Ga)citrate with the nucleus of the osteoclasts is unique and different from tumor cells in which there is a high association of (/sup 67/Ga)citrate with the lysosome fraction within the cytoplasm.

• Research Organization: Univ. of Southern California, Los Angeles (USA)
• OSTI ID: 6973683
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BIOPSY
BODY
CARBOXYLIC ACID SALTS
CELL CONSTITUENTS
CELL NUCLEI
CITRATES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
GALLIUM 67
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MICROSCOPY
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SKELETAL DISEASES
SKELETON
UPTAKE