Separation of technetium hydroxyethylidene diphosphonate complexes by anion-exchange high performance liquid chromatography
Journal Article
·
· Anal. Chem.; (United States)
An anion-exchange high performance liquid chromatographic separation of technetium hydroxyethylidene diphosphonate (Tc-HEDP) complexes has been developed. Samples were prepared by the reduction of TcO/sub 4//sup -/ in the presence of HEDP with NaBH/sub 4/. Samples contained millimolar concentrations of /sup 99/Tc carrier and nanomolar concentrations of the ..gamma..-emitting /sup 99m/Tc isotope. Three modes of detection were used: (1) single wavelength at 405 nm, (2) uv-visible rapid scanning from 250 to 600 nm, and (3) single channel radiometric scintillation. The chromatograms illustrate that these radiopharmaceutical analogues consist of mixtures of at least seven Tc-containing species of unknown oxidation state, central metal configuration, and coordination environment. The distribution of components in these mixtures is dependent on reaction time and the presence of molecular oxygen. 9 figures, 1 table.
- Research Organization:
- Univ. of Cincinnati, OH
- OSTI ID:
- 5346709
- Journal Information:
- Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 52:7; ISSN ANCHA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Development of more efficacious TC-99M organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures. Progress report, May 1, 1983-April 1, 1984
Thesis/Dissertation
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:7191022
Characterization of technetium hydroxyethylidene diphosphonate complexes prepared by sodium borohydride reduction
Thesis/Dissertation
·
Mon Dec 31 23:00:00 EST 1984
·
OSTI ID:5897176
Development of more efficacious TC-99M organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures. Progress report, May 1, 1983-April 1, 1984
Technical Report
·
Sat Dec 31 23:00:00 EST 1983
·
OSTI ID:5234471
Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
400103 -- Radiometric & Radiochemical Procedures-- (-1987)
ANIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHARGED PARTICLES
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DATA
DRUGS
ELEMENTS
EXPERIMENTAL DATA
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ION EXCHANGE CHROMATOGRAPHY
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
METALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
QUANTITATIVE CHEMICAL ANALYSIS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOMETRIC ANALYSIS
RADIOPHARMACEUTICALS
REFRACTORY METALS
SEPARATION PROCESSES
SPECTRA
TECHNETIUM
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSITION ELEMENTS
ULTRAVIOLET SPECTRA
VISIBLE SPECTRA
YEARS LIVING RADIOISOTOPES
400102* -- Chemical & Spectral Procedures
400103 -- Radiometric & Radiochemical Procedures-- (-1987)
ANIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHARGED PARTICLES
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DATA
DRUGS
ELEMENTS
EXPERIMENTAL DATA
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ION EXCHANGE CHROMATOGRAPHY
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
METALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
QUANTITATIVE CHEMICAL ANALYSIS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOMETRIC ANALYSIS
RADIOPHARMACEUTICALS
REFRACTORY METALS
SEPARATION PROCESSES
SPECTRA
TECHNETIUM
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSITION ELEMENTS
ULTRAVIOLET SPECTRA
VISIBLE SPECTRA
YEARS LIVING RADIOISOTOPES