Development of more efficacious TC-99M organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures. Progress report, May 1, 1983-April 1, 1984

Technical Report · Sun Jan 01 04:00:00 EST 1984

OSTI ID:5234471

Heineman, W R

It has been demonstrated that formulation variables (pH, TcO/sub 4//sup -/ concentration, and ligand-to-metal ratio) influence the chromatographic distribution of the components of a Tc-hydroxyethylidene diphosphonate (HEDP) mixture prepared by the NaBH/sub 4/ reduction of TcO/sub 4//sup -/ in the presence of HEDP. The use of alternate reductants for TcO/sub 4//sup -/ (i.e., SnCl/sub 2/, and electrode) not only alters the relative proportion of the Tc-HEDP components formed, but produces new complexes not previously seen (based on chromatographic retention time data). Thus, a systematic evaluation has been undertaken of the SnCl/sub 2/ and electrochemical reduction preparations that is similar to that conducted for Tc(NaBH/sub 4/)-HEDP mixtures. High performance liquid chromatography with electrochemical detection has been utilized to separate components of a Tc(NaBH4)-methylene diphosphonate mixture. All Tc components of the mixture are reducible at a mercury electrode and hydrodynamic voltammetric data is being generated. Stripping chronocoulometry has been developed as a novel variation of anodic stripping voltammetry in order to increase precision in the analytical determination of TcO/sub 4//sup -/ in aqueous solution. Pilot studies to evaluate the operating parameters of /sup 99/Mo//sup 99m/Tc/ generators and to investigate two new diphosphonate ligands in the preparation of technetium skeletal imaging radiopharmaceutical analogs have been initiated.

• Research Organization: Cincinnati Univ., OH (USA). Dept. of Chemistry
• DOE Contract Number: AC02-80EV10380
• OSTI ID: 5234471
• Report Number(s): DOE/EV/10380-4; ON: DE84007336
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BOROHYDRIDES
BORON COMPOUNDS
CHEMICAL PREPARATION
CHEMICAL REACTION KINETICS
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTROCHEMISTRY
EVALUATION
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MOLYBDENUM 99
MOLYBDENUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHONATES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
SEPARATION PROCESSES
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TIN CHLORIDES
TIN COMPOUNDS
TIN HALIDES
TRANSITION ELEMENT COMPOUNDS
VOLTAMETRY
YEARS LIVING RADIOISOTOPES