Adriamycin and x-radiation effects upon an experimental solid tumor resistant to therapy. [Rats]
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5339024
Ten mg/kg Adriamycin to hepatoma H-4-II-E bearing rats cause a significant slowdown in tumor growth and a 10% rat kill. Assays for clonogenicity fail to detect tumor cell-kill at this dose, however. Fifteen hundred rad x-rays cause a comparable growth delay, but also reduce the clonogenic fraction to 0.02. Adriamycin treatment of previously irradiated tumors at a point in tumor regrowth when maximum sensitivity to this agent is expected fails to cause additional cell-kill or delay the time of recovery of the clonogenic fraction.
- Research Organization:
- Univ. of Virginia, Charlottesville
- OSTI ID:
- 5339024
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBIOTICS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
CELL CULTURES
CLONE CELLS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GROWTH
HEPATOMAS
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MORTALITY
NEOPLASMS
NUMERICAL DATA
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
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TIME DEPENDENCE
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X RADIATION
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBIOTICS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
CELL CULTURES
CLONE CELLS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GROWTH
HEPATOMAS
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MORTALITY
NEOPLASMS
NUMERICAL DATA
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RECOVERY
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
VOLUME
X RADIATION