Interaction of radiation and Adriamycin on the EMT6 tumor as a function of tumor size and assay method

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5236262

Fu, K K; Begg, A B; Kane, L J; Phillips, T L

The interaction of radiation and Adriamycin (ADR) in vivo was studied in 3 different sizes of the EMT6/SF tumor, i.e., 1 cm flank tumors, 2 mm macroscopic lung nodules, and microscopic pulmonary metastases. For the flank tumors the drug was slightly more effective when administered intravenously (IV) than intraperitoneally when survival was assayed in vitro at 24 hours after drug treatment. No significant cell kill or growth delay was observed at doses below 15 mg/kg when the response was assayed with the lung colony assay and regrowth analysis. When ADR was combined with radiation, there was no significant difference in survival with variation of the time interval between drug and radiation administration from -48 h to +48 h. When flank tumors were treated with ADR, 15 mg/kg IV, followed in 24 h by graded doses of radiation, additive killing effect was seen at low radiation doses but the survival levels were the same as radiation alone at high doses. Adriamycin was slightly more effective against 2 mm artificial macroscopic pulmonary metastases than the flank tumors, but it did not cause significant changes in the radiation dose response curve of these tumors. When the EMT6/SF tumor cells were treated in the lungs 24 h after transplantation, there was increased cell kill with ADR alone when compared to the 2 mm macroscopic metastases and 1 cm flank tumors. The combined effects of ADR and radiation for the microscopic pulmonary metastases appeared to be strictly additive killing.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5236262
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
IRRADIATION
ISOLATED VALUES
LUNGS
MAMMALS
METASTASES
MICE
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SIZE
SURVIVAL CURVES
TIME DEPENDENCE
TUMOR CELLS
VERTEBRATES