Effect of time between x-irradiation and chemotherapy on the growth of three solid mouse tumors. I. Adriamycin

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5275151

Twentyman, P R; Kallman, R F; Brown, J M

Experiments have been carried out to determine the effect of different time intervals between x-irradiation (1200 rad) and the administration of Adriamycin (ADR) (6 mg/kg) on the growth delay produced in 3 mouse tumors. The tumors used were the EMT6/St/i.d. tumor in BALB/c mice and the KHT and RIF-1 sarcomas in C3H mice. All tumors were grown intramuscularly in the gastrocnemius muscle and treatment was carried out at a mean tumor weight of 450 mg. Time to reach 2X (for KHT) or 4X (for EMT6/St/i.d. and RIF-1) treatment volume was used as the endpoint of response. The drug was administered by the intraperitoneal route either 24, 6, or 2 h before radiation, immediately before the start of radiation, or 3, 6, or 24 h after radiation. All irradiations were carried out in unanesthetized mice. For a single administration at this dose level (close to the maximum tolerated dose), ADR alone produced only minimal growth delay in any of the tumors. Furthermore, the growth delays produced by drug/radiation combinations were not significantly different from the addition of the growth delays produced by the single modalities.

• Research Organization: Stanford Univ., CA
• OSTI ID: 5275151
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GROWTH
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LOCAL IRRADIATION
MAMMALS
MICE
MUSCLES
NEOPLASMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
TIME DEPENDENCE
TUMOR CELLS
VERTEBRATES
X RADIATION