Interaction between adriamycin and radiation in a solid murine tumor
Journal Article
·
· Radiat. Res.; (United States)
Combinations of single and multiple doses of adriamycin and radiation were studied in EMT-6/Ro tumor-bearing BALB/cKa mice. The response to these chemotherapy-radiotherapy treatments was determined using a tumor growth delay assay. The single-dose was found to be additive for both a 2- and 120-hr interval between agents when changes in tumor size were accounted for. When a single dose, two equal doses, or multiple daily doses of adriamycin (all to the same total dose) were combined with a course of ten 200-rad fractions given in 12 days, the resultant tumor growth delays also were in keeping with an additive response between the two treatment modalities. However, in combination with fractionated radiotherapy, a large single dose of adriamycin was more effective than concurrent small daily adriamycin exposures.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 6880283
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
ANTIBIOTICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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CESIUM 137
CESIUM ISOTOPES
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DOSES
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EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GROWTH
INFORMATION
IRRADIATION
ISOTOPES
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
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560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
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BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CESIUM 137
CESIUM ISOTOPES
CHEMOTHERAPY
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GROWTH
INFORMATION
IRRADIATION
ISOTOPES
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SYNERGISM
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VERTEBRATES
WEIGHT
YEARS LIVING RADIOISOTOPES