Effects of bleomycin and irradiation on euoxic and hypoxic cells
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5334004
EMT6 cells in vitro were exposed to bleomycin (BLM), either alone (under euoxic or hypoxic conditions) or in conjunction with x-radiation. Hypoxic and euoxic cells were equally sensitive to the drug in both of the systems used to induce hypoxia (ampules or chambers). Exposure to BLM immediately before x-irradiation altered the shape of the radiation survival curve decreasing the D/sub 0/ by a factor of 1.3. Simultaneous exposure to x-ray and BLM resulted in lower survivals than when radiation was given either before or after drug treatment. Cells recovered quickly from BLM damage if trypsinization was delayed. The results indicate that BLM and x-rays interact to lower cell survival but that cells recover from this effect if trypsinization is delayed.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5334004
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of bleomycin on aerated and hypoxic cells in vitro, in combination with irradiation
Effects of Adriamycin and x-rays on euoxic and hypoxic EMT-6 cells in vitro
Effects of combined bleomycin and irradiation on a solid murine tumor
Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5334011
Effects of Adriamycin and x-rays on euoxic and hypoxic EMT-6 cells in vitro
Conference
·
Wed Aug 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5333790
Effects of combined bleomycin and irradiation on a solid murine tumor
Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5236362
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLEOMYCIN
BODY
CELL CULTURES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
EXPERIMENTAL DATA
GLANDS
HYDROLASES
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMARY GLANDS
NUMERICAL DATA
ORGANS
OXYGEN ENHANCEMENT RATIO
PEPTIDE HYDROLASES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RECOVERY
RESPONSE MODIFYING FACTORS
SURVIVAL CURVES
TRYPSIN
TUMOR CELLS
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLEOMYCIN
BODY
CELL CULTURES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
EXPERIMENTAL DATA
GLANDS
HYDROLASES
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMARY GLANDS
NUMERICAL DATA
ORGANS
OXYGEN ENHANCEMENT RATIO
PEPTIDE HYDROLASES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RECOVERY
RESPONSE MODIFYING FACTORS
SURVIVAL CURVES
TRYPSIN
TUMOR CELLS
X RADIATION