Effects of Adriamycin and x-rays on euoxic and hypoxic EMT-6 cells in vitro
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5333790
EMT-6 mouse tumor cells were grown in vitro and exposed to Adriamycin (and six other drugs) under conditions of euoxia, acute hypoxia or chronic hypoxia. Although the sensitivity of these cells (assayed as colony formation) was somewhat different than other EMT-6 cell lines and varied considerably from drug to drug, there was no difference between euoxic and hypoxic conditions. Moreover, Adriamycin did not consistently affect the radiation survival of these EMT-6 cells and specifically did not modify the shoulder region of the x-ray survival curve.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5333790
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL KILLING
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MICE
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
TUMOR CELLS
VERTEBRATES
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL KILLING
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MICE
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
TUMOR CELLS
VERTEBRATES
X RADIATION