Effects of combined bleomycin and irradiation on a solid murine tumor
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5236362
The effectiveness of bleomycin (BLM) and radiation, both alone and combined, against the EMT6/SF tumor growing subcutaneously in mice was studied using the growth delay and in vitro assays. In experiments investigating the time course of the interaction between the 2 agents, 20 or 40 mg/kg BLM was given between 48 hr before and 48 hr after 800 rad. In 3 out of 4 experiments the effect of the combined treatment at several time intervals was only equal to or less than that of the x-rays alone, even though the drug alone produced up to 70% cell killing and a 3 day growth delay. The regrowth rates of tumors after combined treatment were faster than that after x-rays alone resulting in the proportionally shorter growth delays. Experiments in which untreated tumor cells were transplanted into mice pretreated either with x-rays or BLM plus x-rays showed that BLM did not allow faster regrowth by reducing the x-ray tumor bed effect.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5236362
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
- Country of Publication:
- United States
- Language:
- English
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Conference
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
DATA
DATA FORMS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GROWTH
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LOCAL IRRADIATION
MAMMALS
MICE
NEOPLASMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
TUMOR CELLS
VERTEBRATES
X RADIATION
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
DATA
DATA FORMS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GROWTH
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LOCAL IRRADIATION
MAMMALS
MICE
NEOPLASMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
TUMOR CELLS
VERTEBRATES
X RADIATION