Angiotensin II causes a dual effect on potassium permeability in adrenal glomerulosa cells

Journal Article · Mon Feb 01 04:00:00 EST 1988 · Am. J. Physiol.; (United States)

OSTI ID:5299009

Lobo, M V; Marusic, E T

In previous studies it was shown that angiotensin II causes a Ca-dependent increase in the K permeability of bovine adrenal glomerulosa cells. Here we show that angiotensin II causes a significant and prolonged reduction in the /sup 86/Rb release immediately after the transient rise in /sup 86/Rb efflux. This inhibition was dose related. Apamin (100 nM) and tetraethylammonium (10 mM) completely abolished the initial transient rise in /sup 86/Rb efflux without affecting the latter sustained phase of reduced radioisotope release. On the contrary, the effect of angiotensin II on the second phase was absent when Ca was removed from the perifusion medium or replaced with Sr, but the effect on the early transient phase of /sup 86/Rb efflux was maintained in the absence of external Ca. An additional finding was the increased coefficient rate of /sup 86/Rb efflux that occurred when the cells were depolarized with 12 mM K. However, this effect was not observed when the inhibitory phase due to angiotensin II was fully developed and Ca was present in the external media. On the other hand, the biphasic effect of angiotensin II was still present in depolarized cells. These results suggest that angiotensin II may modulate membrane potential by changes in K permeability of the bovine adrenal glomerulosa cells.

• Research Organization: Univ. of Chile, Santiago
• OSTI ID: 5299009
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 254; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
ALKALI METAL ISOTOPES
ALKALI METALS
ALKALINE EARTH METALS
AMINE OXIDASES
ANGIOTENSIN
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CALCIUM
CARDIOVASCULAR AGENTS
CATTLE
CELL CONSTITUENTS
CELL MEMBRANES
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
DRUGS
ELECTROPHORESIS
ELECTROPHYSIOLOGY
ELEMENTS
ENDOCRINE GLANDS
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
GLANDS
GLOBULINS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MAN
MEMBRANE TRANSPORT
MEMBRANES
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PERMEABILITY
PHYSIOLOGY
POTASSIUM
PRIMATES
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RUBIDIUM 86
RUBIDIUM ISOTOPES
RUMINANTS
STRONTIUM
TRACER TECHNIQUES
VASOCONSTRICTORS
VERTEBRATES