Rapid effects of angiotensin-II on polyphosphoinositide metabolism in the rat adrenal glomerulosa

Journal Article · Sat Dec 31 23:00:00 EST 1983 · Endocrinology; (United States)

OSTI ID:6748761

Farese, R V; Larson, R E; Davis, J S

Angiotensin-II (A-II) provoked a rapid decrease in /sup 32/p in triphosphoinositide (TPI) in /sup 32/p-prelabeled rat adrenal glomerulosa cells. This effect (presumably reflecting TPI hydrolysis) of A-II was nearly maximal at 5 sec of incubation and appeared to precede increases in labeling of phosphatidic acid and phosphatidylinositol. Other aldosterone-stimulating agents (ACTH, K+ and serotonin) did not provoke this effect. Since this effect appeared to be independent of Ca++, it is possible that TPI hydrolysis may be important for Ca++ mobilization during A-II action in glomerulosa tissue.

• Research Organization: Univ. of South Florida, Tampa
• OSTI ID: 6748761
• Journal Information: Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 114:1; ISSN ENDOA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
ALKALINE EARTH METALS
ANGIOTENSIN
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CALCIUM
CARDIOVASCULAR AGENTS
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
ENDOCRINE GLANDS
GLANDS
GLOBULINS
GLOMERULI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
KINETICS
LIGHT NUCLEI
MAMMALS
METABOLISM
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
TRACER TECHNIQUES
VASOCONSTRICTORS
VERTEBRATES