Rapid effects of angiotensin-II on polyphosphoinositide metabolism in the rat adrenal glomerulosa

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Endocrinology; (United States)

OSTI ID:6748761

Farese, R V; Larson, R E; Davis, J S

Angiotensin-II (A-II) provoked a rapid decrease in /sup 32/p in triphosphoinositide (TPI) in /sup 32/p-prelabeled rat adrenal glomerulosa cells. This effect (presumably reflecting TPI hydrolysis) of A-II was nearly maximal at 5 sec of incubation and appeared to precede increases in labeling of phosphatidic acid and phosphatidylinositol. Other aldosterone-stimulating agents (ACTH, K+ and serotonin) did not provoke this effect. Since this effect appeared to be independent of Ca++, it is possible that TPI hydrolysis may be important for Ca++ mobilization during A-II action in glomerulosa tissue.

• Research Organization: Univ. of South Florida, Tampa
• OSTI ID: 6748761
• Journal Information: Endocrinology; (United States), Vol. 114:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
BIOLOGICAL EFFECTS
POLYPEPTIDES
METABOLISM
ADRENAL GLANDS
ANIMAL CELLS
BIOCHEMICAL REACTION KINETICS
CALCIUM
CATIONS
GLOMERULI
PHOSPHORUS 32
RATS
TRACER TECHNIQUES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
ENDOCRINE GLANDS
GLANDS
GLOBULINS
IONS
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
KINETICS
LIGHT NUCLEI
MAMMALS
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RODENTS
VASOCONSTRICTORS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques