Cytogenetic effects of shale-derived oils and related by-products in mice

Technical Report · Tue Jul 01 04:00:00 EDT 1980

DOI:https://doi.org/10.2172/5298474· OSTI ID:5298474

Meyne, J; Deaven, L L

The cytogenetic effects of exposure to crude shale oil by either skin painting or intraperitoneal injectional and transplacental exposure of embryos to water derived from surface retort processing of shale oil were analyzed. Exposure to crude shale oils from two sources, Paraho and Occidental, by skin painting had essesntially no effect on the frequency of chromosomal aberrations in bone marrow cells. Intraperitoneal injection of the Paraho crude shale oil increased the frequency of chromosome damage in bone marrow cells at all three doses tested (0.5 ml, 1.0 ml, and 2.0 ml/kg). Metaphase analysis of cells from embryos at day 12 gestation from females that had been exposed to 1% Paraho retort water ad libitum from day 1 of gestation indicated that clastogenic compounds present in this water can cross the placenta and induce chromosomal damage in embryonic cells.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 5298474
• Report Number(s): LA-8445-MS
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DATA
EMBRYOS
ENERGY SOURCES
EXPERIMENTAL DATA
FOSSIL FUELS
FUELS
IN VIVO
INFORMATION
INGESTION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
MICE
MINERAL OILS
MUTATIONS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
RODENTS
SHALE OIL
SOMATIC CELLS
SYNTHETIC FUELS
SYNTHETIC PETROLEUM
TERATOGENESIS
VERTEBRATES